The Hyphal Tip: Fungal Genomes and Comparative Genomics

Digesting the fungal genomes

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Entries from September 2007

Evolution of aflatoxin gene cluster

Posted on September 29th, 2007 by Jason Stajich · 1 Comment

Blogging on Peer-Reviewed ResearchIgnazio Carbone and colleagues published a recent analysis of the evolution of the aflatoxin gene cluster in five Aspergillus fungi entitled "Gene duplication, modularity and adaptation in the evolution of the aflatoxin gene cluster" in BMC Evolutionary Biology.
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Categories: PKS · aflatoxin · aspergillus · bioinformatics · comparative · gene cluster · human pathogen · molecular evolution · secondary metabolite

New machines

Posted on September 26th, 2007 by Jason Stajich · No Comments

If all went well you didn't even notice... We migrated wiki and blog to new web server in Berkeley out of its kind hosting at OBF servers in Boston area.  We've started the process of rebuilding the genome browser data similar to what was deployed at fungal.genome.duke.edu server, but we are redeveloping the data dumping and importing scripts to be more automatic. 
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Categories: news

Neurospora alternative splicing

Posted on September 21st, 2007 by Jason Stajich · No Comments

mitochondriaA quick link to a Neurospora paper in Genetics today entitled "Alternative Splicing Gives Rise to Different Isoforms of the Neurospora crassa Tob55 Protein That Vary in Their Ability to Insert Beta-Barrel Proteins Into the Outer Mitochondrial Membrane". The authors investigated alternative splicing of a gene found in the TOB complex on the outside of the mitochondria.
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Categories: alternative splicing · mRNA splicing · neurospora

Gene knockouts in Candida parapsilosis

Posted on September 18th, 2007 by Jason Stajich · 1 Comment

Cparapsilosis from G.ButlerA recent paper "Targeted gene deletion in Candida parapsilosis demonstrates the role of secreted lipase in virulence", from the Nosanchuk lab at Yeshiva University, shows the role of secreted lipases in virulence of this pathogen.
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Categories: candida · functional · gene function · gene knockout · human pathogen · pathogens

Fusarium graminearum genome published

Posted on September 8th, 2007 by Jason Stajich · 1 Comment

The genome of the wheat and cereal pathogen Fusarium graminearum was published in Science this week in an article entitled "The Fusarium graminearum Genome Reveals a Link Between Localized Polymorphism and Pathogen Specializationtion". The project was a collaboration of many different Fusarium research groups.
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Categories: RIP · filamentous · fusarium · genome · genome annotation · genome sequencing · plant pathogen

Tracking honeybee decline

Posted on September 6th, 2007 by Jason Stajich · 3 Comments

HoneybeeAn early access to article in Science A Metagenomic Survey of Microbes in Honey Bee Colony Collapse Disorder (direct link since DOI is not updated yet) using the current favorite buzzword, metagenomics, of course, describes some early work to try and discover what is killing the honeybees.
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Categories: honeybee · metagenomics · virus