The Hyphal Tip: Fungal Genomes and Comparative Genomics

Digesting the fungal genomes

The Hyphal Tip: Fungal Genomes and Comparative Genomics header image 4

S.pombe telomerase RNA identified

Posted on January 27th, 2008 by Jason Stajich · No Comments

Blogging on Peer-Reviewed Research Webb, C.J., Zakian, V.A. (2008). Identification and characterization of the Schizosaccharomyces pombe TER1 telomerase RNA. Nature Structural & Molecular Biology, 15(1), 34-42. DOI: 10.1038/nsmb1354

Leonardi, J., Box, J.A., Bunch, J.T., Baumann, P. (2008). TER1, the RNA subunit of fission yeast telomerase. Nature Structural & Molecular Biology, 15(1), 26-33. DOI: 10.1038/nsmb1343

Two papers in Nature Structural & Molecular Biology identify the telomerase RNA in Schizosaccharomyces pombe. Telomerase is a multi-unit enzyme that has both protein and RNA components. While the protein subunit is highly conserved and identifiable through sequence comparisons of eukaryotes, the RNA subunit has a variable size and sequence making identification through comparative means more difficult. The S. pombe telomerase RNA subunit, or TER1, was discovered by two labs applying similar biochemical approaches to identify the locus.

Click to continue reading "S.pombe telomerase RNA identified"

[Read more →]

Categories: cell biology · s.pombe