This month’s Genetics has a series of articles exploring the genome (published last year & freely available at Science) of the green algae Chlamydomonas reinhardtii. These manuscripts are primarily genome analyses making for a very bioinformatics focused issue of Genetics. Some of the highlights include:

• Exploration of snoRNAs finding that a large fraction are clustered in the genome and located in introns.
• Description of transcription factors and their evolutionary conservation and potential link to multicellularity.
• Duplication and diversification of the RNA processing machinery for small RNA mediated silencing.
• Gleaning additional information from Chlamy ESTs that have been over-trimmed.
• Integrating metabolomics and proteomics into better genome annotation.
• Evolution of signaling proteins found in multicellular animals and now Chlamydomonas.