a mushroom and a microsporidia walk into a bar

These papers got lost in my drafts of things to write about.  Grants and overdue manuscripts are keeping me away from the blog.

  • Published work from Gary Foster’s lab in Applied Env Micro show progress on genetic engineering tools to express introduced genes in the basidiomycete mushroom system Clitopilus passeckerianus. C. passeckarianus produces an antibiotic, pleuromutilin, an important antibiotic. Cover photo [Press] They also showed the  5′ intron is important for efficient expression, something that has been shown several times in fungi and provides more evidence for the role of introns in promoting or regulating an aspect of gene expression or translation. Perhaps by splicing-dependent export.
  • Corradi et al – the genome of the microsporidia parasite of Daphnia (water flea). It’s as big as a fungal genome at 24Mb (S.cerevisiae is about 12Mb, Neurospora crassa about 40Mb) but only has about 2,100 genes (S.cerevisiae has ~6,000, N.crassa ~ 10,000). DOI: 10.1186/gb-2009-10-10-r106

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