The roundup of twittered updates for 2010-07-13

  • RT @doe_jgi: Greater enzyme variety for breaking down plant mass found in genome of wood-decay fungus S. commune: #
  • RT @doe_jgi Split-gill fungus is the third wood-decaying fungus sequenced by DOE JGI. Learn what the first two were at #
  • RT @mike_challen: Genome sequence of S commune — now in Nature Biotechnology — Congratulations to the Schizo team #
  • Conidia but not yeast of fungal pathogn H capsulatum trigger Type I interferon innate immune resp in murine macrophages #

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Genome sequence of mushroom Schizophyllum commune

Schizophyllum CommuneI am excited to announce the publication of another mushroom genome this week. The mushroom Schizophyllum commune is an important model system for mushroom biology, development of genome was sequenced as part of efforts at the Joint Genome Institute and a collection of international researchers.  The data and analyses from these efforts are presented in a publication appearing in Nature Biotechnology today.

Studies in mushrooms can have important impact on other research areas.  They can be useful in biotechnology as protein biosynthesis factories for producing compounds or even as an edible delivery mechanism for new drugs.  What we found in the analysis of this genome include clues to mechanisms of how white rotting fungi degrade lignin through analysis of enzyme families.  We also saw evidence for extensive antisense transcription during different developmental stages suggesting some important clues as to how some gene regulation could impact or control developmental progression.  Through gene expression comparison (by MPSS) a large number of transcription factors were shown to be differentially regulated during sexual development.  A knockout out two of these (fst3 and fst4) resulting in changes in ability to form mushrooms (fst4) or smaller mushrooms (fst3).

Several more interesting findings in this work that I hope to add back to this post when there is a little more time –

Ohm, R., de Jong, J., Lugones, L., Aerts, A., Kothe, E., Stajich, J., de Vries, R., Record, E., Levasseur, A., Baker, S., Bartholomew, K., Coutinho, P., Erdmann, S., Fowler, T., Gathman, A., Lombard, V., Henrissat, B., Knabe, N., Kües, U., Lilly, W., Lindquist, E., Lucas, S., Magnuson, J., Piumi, F., Raudaskoski, M., Salamov, A., Schmutz, J., Schwarze, F., vanKuyk, P., Horton, J., Grigoriev, I., & Wösten, H. (2010). Genome sequence of the model mushroom Schizophyllum commune Nature Biotechnology DOI: 10.1038/nbt.1643

The roundup of twittered updates for 2010-07-06

  • QIP, A Comp of Vegetative RNA Silencing Pathway, is Essential for Meiosis & Suppresses Meiotic Silencing in N. crassa #
  • Mating-type orthologous genes in primarily homothallic M perniciosa, the causal agent of Witches' Broom Dx in cacao. #
  • Effect of different stresses on trehalose levels in Rhizopus oryzae. #
  • Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host. #
  • Fungal cell gigantism during mammalian infection. #
  • Origin and fate of pseudogenes in Hemiascomycetes: a comparative analysis. #

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The roundup of twittered updates for 2010-07-05

  • Evolutionary genomics revealed interkingdom distribution of Tcn1-like Gypsy LTR retrotransposons among fungi and plants #
  • Transcriptional reg of chitin synth by calcineurin ctls paradoxical growth of A. fumigatus in response to caspofungin #
  • Systematic analysis of essential genes reveals important regulators of G protein signaling #
  • Genes acquired by HT are potentially involved in the evolution of phytopathogenicity in 2 pathogens of cacao #
  • GREAT pub last year. Trikaryon formation & nuclear selection in pairings btwn heterokaryons & homokaryons of basidio. #

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