Few fungi+host papers

Three papers on some cool fungi that interact with hosts and I recommend them for a good read.

One is coverage of by Ed Yong on rice blast (Magnaporthae orzyae) on paper from Nick Talbot and Gero Steinberg‘s lab on appressorium development in Science this week.

A paper from my lab on role of an expansion of copy number of a chitin-binding domain in the amphibian pathogen B. dendrobatidis.

New Scientist also provides a nice summary of tripartite symbiosis paper on Metarhizium, insects, and plants from Mike Bidochka’s lab.

Hello from ISHAM 2012

I am enjoying a wonderful visit to Berlin for the ISHAM 2012 conference. This meeting is at the intersection of clinical and basic researchers focused on Mycoses. Take a look at the program for a peek at what was presented. The sessions have covered a variety of tool-based, genetics, and applications of antifungals in treatments of mycoses. The connection to animal infections as well as human is especially important as there are some good lessons learned from each systems.

One thing that has become abundantly clear to me is the importance of Candida glabrata as a research system as well as clinically relavant system. I have been particularly interested in studies that have highlighted the variability in the cell wall such as work presented by Piet de Groot on Adhesins (see Kraneveld et al 2011). Jure Piskur gave a provocative talk on why C. glabrata is a haploid through some comparisons of forced diploids made in the lab and profiling of growth and metabolism. Geraldine Butler also gave a nice talk on evolution of the hypoxic response. Many other talks on C. glabrata that highlight its importance and distinct adaptations and this is clearly different from C. albicans.

Several other interesting sessions on fungal genomics, systems biology, evolution and comparative genomics of fungi, the fungal cell wall. For example, Carol Munro spoke about the new tools to develop the Candida ORFeome and over expression constructs. Several new genome sequences were described from Athlete’s foot, microsporida that infect C. elegans, basal Mucormycotina, and dandruff causing Malassezia fungi.

I also want to highlight that this has been one of the most organized and well run conferences I have been to in a while. The Interplan conference organizer really has done an excellent job and the bcc conference venue in Berlin is really well equipped. Let’s see more conferences in Berlin please!

The roundup of twittered updates for 2012-06-02

  • Excellent PLoS Pearl: "Hydrophobins—Unique Fungal Proteins" http://t.co/JJYPhRCM #
  • Extracellular Superoxide Dismutase Protects Histoplasma Yeast Cells from Host-Derived Oxidative Stress http://t.co/ruje6VDk #
  • Global Analysis of the Evolution and Mechanism of Echinocandin Resistance in Candida glabrata http://t.co/jCJvPAR2 #
  • LargeScale Gene Disruption M.oryzae Ids MC69,a Secreted Protein Req'd for Infection by Monocot & Dicot Fungal Pathogens http://t.co/Sn1oVJFA #

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