Category Archives: dothideomycetes

Phytopathogenic Fungi: what have we learned from genome sequences?

ResearchBlogging.orgA review in Plant Cell from Darren Soanes and colleagues summarizes some of the major findings about evolution of phytopathogenic fungi gleaned from genome sequencing highlighting 12 fungi and 2 oomycetes. By mapping evolution of genes identified as virulence factors as well as genes that appear to have similar patterns of diversification, we can hope to derive some principals about how phytopathogenic fungi have evolved from saprophyte ancestors.

They infer from phylogenies we’ve published (Fitzpatrick et al, James et al) that plant pathogenic capabilities have arisen at least 5 times in the fungi and at least 7 times in the eukaryotes. In addition they use data on gene duplication and loss in the ascomycete fungi (Wapinski et al) to infer there large numbers of losses and gains of genes have occurred in fungal lineages.

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Stagonospora nodorum genome published

Blogging about Peer-Reviewed ResearchThe Stagonospra nodorum (teleomorph Phaeosphaeria nodorum) genome is now published in Plant Cell, “Sequencing and EST Analysis of the Wheat Pathogen Stagonospora nodorum”. The paper describes the sequencing and analysis of this Dothideomycete fungus. The analyses included identifying genes likely involved in pathogenecity such as PKS and NRPS genes and enabled the discovery of new genes like ToxA.

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Genomes on the horizon at JGI

Several more fungi are on the docket for sequencing at JGI through their community sequencing program. This includes

This complements an ever growing list of fungal genome sequences which is probably topping 80+ now not including the several dozen strains of Saccharomyces that are being sequenced at Sanger Centre and a separately funded NIH project to be sequenced at WashU.

Pyrenophora tritici-repentis

The genome of Pyrenophora tritici-repentis, the fourth sequenced Dothideomycete genome, was released by the FGI at the Broad Institute this spring (March 2007). P. tiritici-repentis was sequenced for its role as the cause of tan spot on wheat and as a research model for other Pyrenophora sp. that are pathogens of several grasses.

The 6X assembly contains 37.8 Mb of sequence similar to the other Dothideomycetes such as Stagnospora nodorum (37.2 Mb), Alternaria brassicola (32 Mb), and Mycosphaerella graminicola (41.8 Mb).

Fungal Genetics 2007 details

I’m including a recapping as many of the talks as I remember. There were 6 concurrent sessions each afternoon so you have to miss a lot of talks. The conference was bursting at the seams as it was- at least 140 people had to be turned away beyond the 750 who attended.

If there was any theme in the conference it was “Hey we are all using these genome sequences we’ve been talking about getting”. I only found the overview talks that solely describe the genome solely a little dry as compared to those more focused on particular questions. I guess my genome palate is becoming refined.

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