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How to get A.fumigatus in the mood for love

A manuscript at Nature AOP details the success of the Dyer lab and collaborators in encouraging [[Aspergillus fumigatus]] to complete the sexual cycle under observable (e.g. laboratory) conditions. The authors are the teleomorph (sexual or perfect) stage [[Neosartorya fumigata]] for a fungus that had been previously only had an observed anamorphic stage. A. fumigatus can reproduce asexually forming structures called [[conidiophores]] which produce asexual spores called [[conidiospores]] (or mitospores as they are produced via mitosis) define the anamorph or imperfect stage, but no sexual structures such as [[cleistothecia]] that produce the packaged sexual products as [[ascospores]]. See a presentation by David Geiser (archived at the Aspergillus website) for more detail on some of the morphological and phylogenetic characters that unify the group of Eurotiales [...]

Dermatophyte genome sequences

The first of several dermatophyte fungal genomes, [[Microsporum gypseum]], has been released at the Broad Dermatophyte site.  Two Tricophyton species and another Microsporum genome should follow soon. These dermatophyte fungi are Onygenales (Ascomycota) fungi (like Coccidioides and [...]

Bad reporting

Hyphoid Logic rips on the Alameda Sun for calling Coccidoidies a [...]

Coccidioides in the news

The NY Times has an article on the high rate of Coccidioides incidence at the state prison in Pleasant Valley, California. The infection rate has been documented by Pappagianis et al in an in-depth study of Coccidioidomycosis in the California state prisons. The disease has stalled some plans for constructing a new prison the edge of the San Joaquin Valley so the [...]

Onygenales genome cluster

I’m excited about our projects to tackle the evolution of the Onygenales fungi.

I just remembered to look and see what was going on with the Blastomyces genome sequencing at WashU.  I checked and the Blastomyces dermatitidis genome sequence assembly version 3 was released in October 2007 and ESTs via 454 and ABI technologies are all available from WUSTL Genome Sequencing Center.

With the Broad Institute release this week [...]

More Cocci genomes

The Broad Institute has made available additional genomes of strains of Coccidioides immitis and C. posadasii. There are now genome sequences for 4 strains of C. immitis sequenced and 3 strains of C. posadasii including the C735 strain from the JCVI/TIGR. including the reference strain RS that is assembled into 7 supercontigs (there are probably 5 chromosomes) and annotated with ~10,000 genes. [...]