By Jason Stajich, on July 27th, 2008
Report concludes that a fungal genome database is of “the highest priority”.
This is the title as listed in PubMed for this article from Future Medicine about the AAM report on charting future needs and avenues of research on the fungal kingdom.
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By Jason Stajich, on July 17th, 2008
Just noticed that the [[JGI]] has released the Cochliobolus heterostrophus genome sequence at their site predicting 9,633 protein-coding genes. Torrey Mesa Research Institute had access to a sequence many years ago, but it isn’t until now that public version of this genome is available. Cochliobolus is has been a model plant pathogen system and its production of T-Toxin by a PKS gene (Yang et al) [...]
By Jason Stajich, on June 3rd, 2008
We’re excited that a Penicillium marneffei grant to Mat Fisher and collaborators has been funded by the Welcome Trust. It includes a collaboration with University College London, our lab, JCVI, and Univ of Melbourne. This project will explore functional and comparative genomics approaches to studying the fungus
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By Jason Stajich, on May 12th, 2008
The [[Trichoderma reesei]] genome paper was recently published in Nature Biotechnology from Diego Martinez at [[LANL]] with collaborators at [[JGI]], [[LBNL]], and others. This fungus was chosen for sequencing because it was found on canvas tents eating the cotton material suggesting it may be a good candidate for degrading cellulose plant material as part of cellulosic ethanol production.
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By Jason Stajich, on April 5th, 2008
Another asexual species of fungi also has evidence for the meiosis-specific process of Repeat Induced Point-mutations (RIP). [...]
By Jason Stajich, on February 17th, 2008
What delineates species boundaries in fungi? Much work has been done on biological and phylogenetic species concepts in fungi. Some concepts are reviewed in Taylor et al 2006 and in Taylor et al 2000, and applications can be seen in several pathogens such as Paraccocidiodies, Coccidioides, and the model filamentous (non-pathogenic) fungus Neurospora
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By Jason Stajich, on February 8th, 2008
A review in Plant Cell from Darren Soanes and colleagues summarizes some of the major findings about evolution of phytopathogenic fungi gleaned from genome sequencing highlighting 12 fungi and 2 oomycetes. By mapping evolution of genes identified as virulence factors as well as genes that appear to have similar patterns of diversification, we can hope to derive some principals about how phytopathogenic fungi have evolved from saprophyte ancestors.
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By Jason Stajich, on October 31st, 2007
A paper in PLoS Biology from Sandy Johnson’s lab entitled “Interlocking Transcriptional Feedback Loops Control White-Opaque Switching in Candida albicans” discusses phenotype switching in the human pathogenic fungus Candida albicans. Why is the important?
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By Jason Stajich, on October 9th, 2007
Reverting CUG tRNA from derived change coding for serine back to leucine (standard code) has profound effect on organism. [...]
By Jason Stajich, on September 18th, 2007
A recent paper “Targeted gene deletion in Candida parapsilosis demonstrates the role of secreted lipase in virulence”, from the Nosanchuk lab at Yeshiva University, shows the role of secreted lipases in virulence of this pathogen. [...]
