A nice series of comparative genomics articles have been published in the last few weeks. The pace of genome sequencing has accelerated to the point that we have lots of sequencing projects coming from individual labs and small consortia not necessarily from genome centers. We are seeing a preview of what next (2nd) generation sequencing [...]
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Some tasty research if you are of the set who enjoy a good pint of beer. GenomeWebNews reports on study in Genome Research by Barbara Dunn and Gavin Sherlock at Stanford, looking at the history of lager yeast Saccharomyces pastorianus. [...] The transcriptional landscape of yeast has been (further) defined with [[Solexa]] sequencing in a method deemed “RNA-Seq”, but what I would call “deep EST sequencing”. This approach for transcriptional profiling by sequencing alone is sure to be used by many labs looking for lower and more complete ways to describe and quantitate the full population of transcripts in an organism. [...] EMBO Workshop on Evolutionary and Environmental Genomics of Yeasts A few of the summer meetings that relate to fungal biology and evolution.
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We may have to reevaluate whether Saccharomyces cerevisiae alone is the species used to brew beer. A paper from Gonzalez et al describes results from PCR-RFLP comparison of 24 brewing strains identifies evidence for S. cerevisiae x S. kudriavzevii hybrids. Although this hybridization is not unprecedented, most seem to be related to cultivated brewing or fermentation [...]
Researchers from Technical University of Denmark published some interesting results from comparing expression across the very distinct Aspergillus species. Kudos also goes to making it Open Access. I am posting a few key figures below the fold because I can! They grew the fungi in bioreactors fermenting glucose or xylose. After calibrating the growth curves they were able to sample the appropriate time points for comparison of gene expression across these three species. They found a set of genes commonly expressed.
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I’ve been too busy to post much these last few days, but here are a few links to some papers I found interesting in my recent browsing.
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